Testmiljö
Observera att detta är en testmiljö för utveckling som inte ska användas som underlag för klinisk bedömning. Besök Janusmed här: https://janusmed.se

12/3/2024

Janusmed kön och genus

Janusmed kön och genus – Activase

Janusmed kön och genus är ett kunskapsstöd som tillhandahåller information om köns- och genusaspekter på läkemedelsbehandling. Kunskapsstödet är avsedd främst för hälso- och sjukvårdspersonal. Texterna är generella och ska inte ses som behandlingsriktlinjer. Det är alltid behandlande läkare som ansvarar för patientens medicinering.

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Alteplas Testmiljö

Alteplas

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  1. Acheampong P, Ford GA. Pharmacokinetics of alteplase in the treatment of ischaemic stroke. Expert Opin Drug Metab Toxicol. 2012;8:271-81.

  2. Reeves MJ, Wilkins T, Lisabeth LD, Schwamm LH. Thrombolysis treatment for acute stroke: issues of efficacy and utilization in women. Womens Health (Lond Engl). 2011;7:383-90.

  3. Kent DM, Price LL, Ringleb P, Hill MD, Selker HP. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke. 2005;36:62-5.

  4. Meseguer E, Mazighi M, Labreuche J, Arnaiz C, Cabrejo L, Slaoui T et al. Outcomes of intravenous recombinant tissue plasminogen activator therapy according to gender: a clinical registry study and systematic review. Stroke. 2009;40:2104-10.

  5. Kent DM, Buchan AM, Hill MD. The gender effect in stroke thrombolysis: of CASES, controls, and treatment-effect modification. Neurology. 2008;71:1080-3.

  6. Förster A, Gass A, Kern R, Wolf ME, Ottomeyer C, Zohsel K et al. Gender differences in acute ischemic stroke: etiology, stroke patterns and response to thrombolysis. Stroke. 2009;40:2428-32.

  7. Nathanson, DP, C; Nyström, T; von Euler, M. Sex, Diastolic Blood Pressure, and Outcome after Thrombolysis for Ischemic Stroke. Stroke Research and Treatment. 2014 sep;-:7.

  8. Savitz SI, Schlaug G, Caplan L, Selim M. Arterial occlusive lesions recanalize more frequently in women than in men after intravenous tissue plasminogen activator administration for acute stroke. Stroke. 2005;36(7):1447-51.

  9. Buijs JE, Uyttenboogaart M, Brouns R, de Keyser J, Kamphuisen PW, Luijckx GJ. The Effect of Age and Sex on Clinical Outcome after Intravenous Recombinant Tissue Plasminogen Activator Treatment in Patients with Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2016;25(2):312-6.

  10. Clua-Espuny JL, Ripolles-Vicente R, Forcadell-Arenas T, Gil-Guillen VF, Queralt-Tomas ML, González-Henares MA et al. Sex Differences in Long-Term Survival after a First Stroke with Intravenous Thrombolysis: Ebrictus Study. Cerebrovasc Dis Extra. 2015;5(3):95-102.

  11. Lasek-Bal A, Puz P, Kazibutowska Z. Efficacy and safety assessment of alteplase in the treatment of stroke - gender differences. Neurol Res. 2014;36(9):851-6.

  12. Lorenzano S, Ahmed N, Falcou A, Mikulik R, Tatlisumak T, Roffe C et al. Does sex influence the response to intravenous thrombolysis in ischemic stroke?: answers from safe implementation of treatments in Stroke-International Stroke Thrombolysis Register. Stroke. 2013;44:3401-6.

  13. Spaander FH, Zinkstok SM, Baharoglu IM, Gensicke H, Polymeris A, Traenka C et al. Sex Differences and Functional Outcome After Intravenous Thrombolysis. Stroke. 2017;48(3):699-703.

  14. Elkind MS, Prabhakaran S, Pittman J, Koroshetz W, Jacoby M, Johnston KC et al. Sex as a predictor of outcomes in patients treated with thrombolysis for acute stroke. Neurology. 2007;68(11):842-8.

  15. Martínez-Sánchez P, Fuentes B, Alonso de Leciñana M, Masjuan J, Simal P, Egido J et al. Female gender is a factor of worse outcome in acute stroke even after thrombolytic treatment. Int J Stroke. 2011;6(4):371-2.

  16. Niewada M, Kobayashi A, Sandercock PA, Kamiński B, Członkowska A, International Stroke Trial Collaborative Group. Influence of gender on baseline features and clinical outcomes among 17,370 patients with confirmed ischaemic stroke in the international stroke trial. Neuroepidemiology. 2005;24(3):123-8.

  17. Lincoff AM, Califf RM, Ellis SG, Sigmon KN, Lee KL, Leimberger JD et al. Thrombolytic therapy for women with myocardial infarction: is there a gender gap? Thrombolysis and Angioplasty in Myocardial Infarction Study Group. J Am Coll Cardiol. 1993;22(7):1780-7.

  18. Shah SH, Liebeskind DS, Saver JL, Starkman S, Vinuela F, Duckwiler G et al. Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke. Neurology. 2006;66(11):1745-6.

  19. Shobha N, Sylaja PN, Kapral MK, Fang J, Hill MD, Investigators of the Registry of the Canadian Stroke Network. Differences in stroke outcome based on sex. Neurology. 2010;74(9):767-71.

  20. Tafreshi GM, Raman R, Ernstrom K, Meyer BC, Hemmen TM. Gender differences in acute stroke treatment: the University of California San Diego experience. Stroke. 2010;41(8):1755-7.

  21. Al-hussain F, Hussain MS, Molina C, Uchino K, Shuaib A, Demchuk AM et al. Does the sex of acute stroke patients influence the effectiveness of rt-PA?. BMC Neurol. 2014;14(1):60.

  22. Hametner C, Kellert L, Ringleb PA. Impact of sex in stroke thrombolysis: a coarsened exact matching study. BMC Neurol. 2015;15(1):10.

  23. Mazya MV, Ahmed N, Ford GA, Hobohm C, Mikulik R, Nunes AP et al. Remote or extraischemic intracerebral hemorrhage--an uncommon complication of stroke thrombolysis: results from the safe implementation of treatments in stroke-international stroke thrombolysis register. Stroke. 2014;45:1657-63.

  24. Berkowitz SD, Granger CB, Pieper KS, Lee KL, Gore JM, Simoons M et al. Incidence and predictors of bleeding after contemporary thrombolytic therapy for myocardial infarction The Global Utilization of Streptokinase and Tissue Plasminogen activator for Occluded coronary arteries (GUSTO) I Investigators. Circulation. 1997;95:2508-16.

  25. Weaver WD, White HD, Wilcox RG, Aylward PE, Morris D, Guerci A et al. Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy GUSTO-I investigators. JAMA. 1996;275:777-82.

  26. IST-3 collaborative group. Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial. Lancet Neurol. 2013;12:768-76.

  27. Concise (INSIKT). Kalmar: eHälsomyndigheten. 2018 [cited 2019-03-14.]

  28. Riksstroke - The Swedish Stroke Register. 2018 [cited 2019-03-25].

  1. Acheampong P, Ford GA. Pharmacokinetics of alteplase in the treatment of ischaemic stroke. Expert Opin Drug Metab Toxicol. 2012;8:271-81.
  2. Reeves MJ, Wilkins T, Lisabeth LD, Schwamm LH. Thrombolysis treatment for acute stroke: issues of efficacy and utilization in women. Womens Health (Lond Engl). 2011;7:383-90.
  3. Kent DM, Price LL, Ringleb P, Hill MD, Selker HP. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke. 2005;36:62-5.
  4. Meseguer E, Mazighi M, Labreuche J, Arnaiz C, Cabrejo L, Slaoui T et al. Outcomes of intravenous recombinant tissue plasminogen activator therapy according to gender: a clinical registry study and systematic review. Stroke. 2009;40:2104-10.
  5. Kent DM, Buchan AM, Hill MD. The gender effect in stroke thrombolysis: of CASES, controls, and treatment-effect modification. Neurology. 2008;71:1080-3.
  6. Förster A, Gass A, Kern R, Wolf ME, Ottomeyer C, Zohsel K et al. Gender differences in acute ischemic stroke: etiology, stroke patterns and response to thrombolysis. Stroke. 2009;40:2428-32.
  7. Nathanson, DP, C; Nyström, T; von Euler, M. Sex, Diastolic Blood Pressure, and Outcome after Thrombolysis for Ischemic Stroke. Stroke Research and Treatment. 2014 sep;-:7.
  8. Savitz SI, Schlaug G, Caplan L, Selim M. Arterial occlusive lesions recanalize more frequently in women than in men after intravenous tissue plasminogen activator administration for acute stroke. Stroke. 2005;36(7):1447-51.
  9. Buijs JE, Uyttenboogaart M, Brouns R, de Keyser J, Kamphuisen PW, Luijckx GJ. The Effect of Age and Sex on Clinical Outcome after Intravenous Recombinant Tissue Plasminogen Activator Treatment in Patients with Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2016;25(2):312-6.
  10. Clua-Espuny JL, Ripolles-Vicente R, Forcadell-Arenas T, Gil-Guillen VF, Queralt-Tomas ML, González-Henares MA et al. Sex Differences in Long-Term Survival after a First Stroke with Intravenous Thrombolysis: Ebrictus Study. Cerebrovasc Dis Extra. 2015;5(3):95-102.
  11. Lasek-Bal A, Puz P, Kazibutowska Z. Efficacy and safety assessment of alteplase in the treatment of stroke - gender differences. Neurol Res. 2014;36(9):851-6.
  12. Lorenzano S, Ahmed N, Falcou A, Mikulik R, Tatlisumak T, Roffe C et al. Does sex influence the response to intravenous thrombolysis in ischemic stroke?: answers from safe implementation of treatments in Stroke-International Stroke Thrombolysis Register. Stroke. 2013;44:3401-6.
  13. Spaander FH, Zinkstok SM, Baharoglu IM, Gensicke H, Polymeris A, Traenka C et al. Sex Differences and Functional Outcome After Intravenous Thrombolysis. Stroke. 2017;48(3):699-703.
  14. Elkind MS, Prabhakaran S, Pittman J, Koroshetz W, Jacoby M, Johnston KC et al. Sex as a predictor of outcomes in patients treated with thrombolysis for acute stroke. Neurology. 2007;68(11):842-8.
  15. Martínez-Sánchez P, Fuentes B, Alonso de Leciñana M, Masjuan J, Simal P, Egido J et al. Female gender is a factor of worse outcome in acute stroke even after thrombolytic treatment. Int J Stroke. 2011;6(4):371-2.
  16. Niewada M, Kobayashi A, Sandercock PA, Kamiński B, Członkowska A, International Stroke Trial Collaborative Group. Influence of gender on baseline features and clinical outcomes among 17,370 patients with confirmed ischaemic stroke in the international stroke trial. Neuroepidemiology. 2005;24(3):123-8.
  17. Lincoff AM, Califf RM, Ellis SG, Sigmon KN, Lee KL, Leimberger JD et al. Thrombolytic therapy for women with myocardial infarction: is there a gender gap? Thrombolysis and Angioplasty in Myocardial Infarction Study Group. J Am Coll Cardiol. 1993;22(7):1780-7.
  18. Shah SH, Liebeskind DS, Saver JL, Starkman S, Vinuela F, Duckwiler G et al. Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke. Neurology. 2006;66(11):1745-6.
  19. Shobha N, Sylaja PN, Kapral MK, Fang J, Hill MD, Investigators of the Registry of the Canadian Stroke Network. Differences in stroke outcome based on sex. Neurology. 2010;74(9):767-71.
  20. Tafreshi GM, Raman R, Ernstrom K, Meyer BC, Hemmen TM. Gender differences in acute stroke treatment: the University of California San Diego experience. Stroke. 2010;41(8):1755-7.
  21. Al-hussain F, Hussain MS, Molina C, Uchino K, Shuaib A, Demchuk AM et al. Does the sex of acute stroke patients influence the effectiveness of rt-PA?. BMC Neurol. 2014;14(1):60.
  22. Hametner C, Kellert L, Ringleb PA. Impact of sex in stroke thrombolysis: a coarsened exact matching study. BMC Neurol. 2015;15(1):10.
  23. Mazya MV, Ahmed N, Ford GA, Hobohm C, Mikulik R, Nunes AP et al. Remote or extraischemic intracerebral hemorrhage--an uncommon complication of stroke thrombolysis: results from the safe implementation of treatments in stroke-international stroke thrombolysis register. Stroke. 2014;45:1657-63.
  24. Berkowitz SD, Granger CB, Pieper KS, Lee KL, Gore JM, Simoons M et al. Incidence and predictors of bleeding after contemporary thrombolytic therapy for myocardial infarction The Global Utilization of Streptokinase and Tissue Plasminogen activator for Occluded coronary arteries (GUSTO) I Investigators. Circulation. 1997;95:2508-16.
  25. Weaver WD, White HD, Wilcox RG, Aylward PE, Morris D, Guerci A et al. Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy GUSTO-I investigators. JAMA. 1996;275:777-82.
  26. IST-3 collaborative group. Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial. Lancet Neurol. 2013;12:768-76.
  27. Concise (INSIKT). Kalmar: eHälsomyndigheten. 2018 [cited 2019-03-14.]
  28. Riksstroke - The Swedish Stroke Register. 2018 [cited 2019-03-25].