Testmiljö
Observera att detta är en testmiljö för utveckling som inte ska användas som underlag för klinisk bedömning. Besök Janusmed här: https://janusmed.se

11/21/2024

Janusmed fosterpåverkan

Janusmed fosterpåverkan – dolutegravirnatrium

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

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Dolutegravir Testmiljö

Dolutegravir

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  1. EMA. Tivicay. CHMP Assessment report; 2013-11-21 http://goo.gl/S3dtjH

  2. Lewis JM, Railton E, Riordan A, Khoo S, Chaponda M. Early experience of dolutegravir pharmacokinetics in pregnancy: high maternal levels and significant foetal exposure with twice-daily dosing. AIDS. 2016;30:1313-5.

  3. Ikumi NM, Anumba D, Matjila M. Pharmacokinetics and placental transfer of dolutegravir in pregnancy. J Antimicrob Chemother. 2021.

  4. EMA. New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir. EMA [www]. [updated 2018-05-18, cited 2022-04-12].

  5. Zash R, Holmes L, Diseko M, Jacobson DL, Brummel S, Mayondi G et al. Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana. N Engl J Med. 2019;381(9):827-840.

  6. Raesima MM, Ogbuabo CM, Thomas V, Forhan SE, Gokatweng G, Dintwa E et al. Dolutegravir Use at Conception - Additional Surveillance Data from Botswana. N Engl J Med. 2019;381(9):885-887.

  7. Pereira GFM, Kim A, Jalil EM, Fernandes Fonseca F, Shepherd BE, Veloso VG et al. Dolutegravir and pregnancy outcomes in women on antiretroviral therapy in Brazil: a retrospective national cohort study. Lancet HIV. 2021;8(1):e33-e41.

  8. Vannappagari V, Thorne C, for APR and EPPICC. Pregnancy and Neonatal Outcomes Following Prenatal Exposure to Dolutegravir. J Acquir Immune Defic Syndr. 2019;81(4):371-378.

  9. Money D, Lee T, O'Brien C, Brophy J, Bitnun A, Kakkar F et al. Congenital anomalies following antenatal exposure to dolutegravir: a Canadian surveillance study. BJOG. 2019;126(11):1338-1345.

  10. WHO. UPDATE OF RECOMMENDATIONS ON FIRST- AND SECOND-LINE ANTIRETROVIRAL REGIMENS. WHO [www]. [updated 2019-07-01, cited 2022-04-12].

  11. Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission . Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States. Clinicalinfohivgov [www]. Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission . [updated 2022-03-17, cited 2022-04-12].

  1. EMA. Tivicay. CHMP Assessment report; 2013-11-21 http://goo.gl/S3dtjH
  2. Lewis JM, Railton E, Riordan A, Khoo S, Chaponda M. Early experience of dolutegravir pharmacokinetics in pregnancy: high maternal levels and significant foetal exposure with twice-daily dosing. AIDS. 2016;30:1313-5.
  3. Ikumi NM, Anumba D, Matjila M. Pharmacokinetics and placental transfer of dolutegravir in pregnancy. J Antimicrob Chemother. 2021.
  4. EMA. New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir. EMA [www]. [updated 2018-05-18, cited 2022-04-12].
  5. Zash R, Holmes L, Diseko M, Jacobson DL, Brummel S, Mayondi G et al. Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana. N Engl J Med. 2019;381(9):827-840.
  6. Raesima MM, Ogbuabo CM, Thomas V, Forhan SE, Gokatweng G, Dintwa E et al. Dolutegravir Use at Conception - Additional Surveillance Data from Botswana. N Engl J Med. 2019;381(9):885-887.
  7. Pereira GFM, Kim A, Jalil EM, Fernandes Fonseca F, Shepherd BE, Veloso VG et al. Dolutegravir and pregnancy outcomes in women on antiretroviral therapy in Brazil: a retrospective national cohort study. Lancet HIV. 2021;8(1):e33-e41.
  8. Vannappagari V, Thorne C, for APR and EPPICC. Pregnancy and Neonatal Outcomes Following Prenatal Exposure to Dolutegravir. J Acquir Immune Defic Syndr. 2019;81(4):371-378.
  9. Money D, Lee T, O'Brien C, Brophy J, Bitnun A, Kakkar F et al. Congenital anomalies following antenatal exposure to dolutegravir: a Canadian surveillance study. BJOG. 2019;126(11):1338-1345.
  10. WHO. UPDATE OF RECOMMENDATIONS ON FIRST- AND SECOND-LINE ANTIRETROVIRAL REGIMENS. WHO [www]. [updated 2019-07-01, cited 2022-04-12].
  11. Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission . Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States. Clinicalinfohivgov [www]. Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission . [updated 2022-03-17, cited 2022-04-12].