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10/26/2025

Janusmed sex and gender

Janusmed sex and gender – metoclopramide hydrochloride

Janusmed Sex and Gender is a knowledge database providing information on sex and gender aspects of drug treatment. The knowledge database is primarily intended to be used by physicians and healthcare professionals. The texts are general and should not be considered as treatment guidelines. The individual patient’s physician is responsible for the patient’s drug treatment.

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Metoclopramide testing environment

Metoclopramide

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  1. Fass R, Pieniaszek HJ, Thompson JR. Pharmacokinetic comparison of orally-disintegrating metoclopramide with conventional metoclopramide tablet formulation in healthy volunteers. Aliment Pharmacol Ther. 2009;30:301-6.

  2. Primperan (metoklopramid). Summary of Product Characteristics. Medical Products Agency; 2014.

  3. Roila F, Tonato M, Basurto C, Canaletti R, Morsia D, Passalacqua R et al. Antiemetic activity of two different high doses of metoclopramide in cisplatin-treated cancer patients: a randomized double-blind trial of the Italian Oncology Group for Clinical Research. Cancer Treat Rep. 1985;69:1353-7.

  4. Tsavaris N, Mylonakis N, Bacoyiannis C, Kosmas C, Kalergis G, Iakovidis V et al. Factors that influence the antiemetic activity of metoclopramide to cisplatin based chemotherapy. Oncol Rep. 1998;5:1147-55.

  5. Kreel L, Trott M, Howells TH. The influence of oral metoclopramide on gastric emptying after a fixed water load. Clin Radiol. 1972;23:213-8.

  6. Bateman DN, Rawlins MD, Simpson JM. Extrapyramidal reactions with metoclopramide. Br Med J (Clin Res Ed). 1985;291:930-2.

  7. Pasricha PJ, Pehlivanov N, Sugumar A, Jankovic J. Drug Insight: from disturbed motility to disordered movement--a review of the clinical benefits and medicolegal risks of metoclopramide. Nat Clin Pract Gastroenterol Hepatol. 2006;3:138-48.

  8. Merrill RM, Lyon JL, Matiaco PM. Tardive and spontaneous dyskinesia incidence in the general population. BMC Psychiatry. 2013;13:152.

  9. Yassa R, Jeste DV. Gender differences in tardive dyskinesia: a critical review of the literature. Schizophr Bull. 1992;18:701-15.

  10. Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J et al. Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. J Clin Gastroenterol. 2012;46:494-503.

  11. Kauppila A, Kivinen S, Ylikorkala O. A dose response relation between improved lactation and metoclopramide. Lancet 1981;1(8231):1175-1177.

  12. Ylikorkala O, Kauppila A. The effects on the ovulatory cycle of metoclopramide-induced increased prolactin levels during follicular development. Fertil Steril. 1981;35:588-9.

  13. Kauppila A, Leinonen P, Vihko R, Ylöstalo P. Metoclopramide-induced hyperprolactinemia impairs ovarian follicle maturation and corpus luteum function in women. J Clin Endocrinol Metab. 1982;54:955-60.

  14. Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-04-05.]

  1. Fass R, Pieniaszek HJ, Thompson JR. Pharmacokinetic comparison of orally-disintegrating metoclopramide with conventional metoclopramide tablet formulation in healthy volunteers. Aliment Pharmacol Ther. 2009;30:301-6.
  2. Primperan (metoklopramid). Summary of Product Characteristics. Medical Products Agency; 2014.
  3. Roila F, Tonato M, Basurto C, Canaletti R, Morsia D, Passalacqua R et al. Antiemetic activity of two different high doses of metoclopramide in cisplatin-treated cancer patients: a randomized double-blind trial of the Italian Oncology Group for Clinical Research. Cancer Treat Rep. 1985;69:1353-7.
  4. Tsavaris N, Mylonakis N, Bacoyiannis C, Kosmas C, Kalergis G, Iakovidis V et al. Factors that influence the antiemetic activity of metoclopramide to cisplatin based chemotherapy. Oncol Rep. 1998;5:1147-55.
  5. Kreel L, Trott M, Howells TH. The influence of oral metoclopramide on gastric emptying after a fixed water load. Clin Radiol. 1972;23:213-8.
  6. Bateman DN, Rawlins MD, Simpson JM. Extrapyramidal reactions with metoclopramide. Br Med J (Clin Res Ed). 1985;291:930-2.
  7. Pasricha PJ, Pehlivanov N, Sugumar A, Jankovic J. Drug Insight: from disturbed motility to disordered movement--a review of the clinical benefits and medicolegal risks of metoclopramide. Nat Clin Pract Gastroenterol Hepatol. 2006;3:138-48.
  8. Merrill RM, Lyon JL, Matiaco PM. Tardive and spontaneous dyskinesia incidence in the general population. BMC Psychiatry. 2013;13:152.
  9. Yassa R, Jeste DV. Gender differences in tardive dyskinesia: a critical review of the literature. Schizophr Bull. 1992;18:701-15.
  10. Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J et al. Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. J Clin Gastroenterol. 2012;46:494-503.
  11. Kauppila A, Kivinen S, Ylikorkala O. A dose response relation between improved lactation and metoclopramide. Lancet 1981;1(8231):1175-1177.
  12. Ylikorkala O, Kauppila A. The effects on the ovulatory cycle of metoclopramide-induced increased prolactin levels during follicular development. Fertil Steril. 1981;35:588-9.
  13. Kauppila A, Leinonen P, Vihko R, Ylöstalo P. Metoclopramide-induced hyperprolactinemia impairs ovarian follicle maturation and corpus luteum function in women. J Clin Endocrinol Metab. 1982;54:955-60.
  14. Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-04-05.]